Search results for "Housekeeping genes"

showing 3 items of 3 documents

Bypassing hazard of housekeeping genes: their evaluation in rat granule neurons treated with cerebrospinal fluid of multiple sclerosis subjects

2015

Gene expression studies employing real-time PCR has become an intrinsic part of biomedical research. Appropriate normalization of target gene transcript(s) based on stably expressed housekeeping genes is crucial in individual experimental conditions to obtain accurate results. In multiple sclerosis (MS), several gene expression studies have been undertaken, however, the suitability of housekeeping genes to express stably in this disease is not yet explored. Recent research suggests that their expression level may vary under different experimental conditions. Hence it is indispensible to evaluate their expression stability to accurately normalize target gene transcripts. The present study ai…

GeneticsBeta-2 microglobulinbusiness.industryMultiple sclerosishousekeeping genesNormFinderTransferrin receptorComputational biologymedicine.diseasemultiple sclerosislcsh:RC321-571Housekeeping geneGeNormCellular and Molecular NeuroscienceReal-time polymerase chain reactionnormalizationReference genesGene expressionmedicinebusinesslcsh:Neurosciences. Biological psychiatry. NeuropsychiatryGeneOriginal ResearchNeuroscience
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Co-Infections by Fusarium circinatum and Phytophthora spp. on Pinus radiata: Complex Phenotypic and Molecular Interactions

2021

13 Pág. Instituto de Ciencias Forestales (ICIFOR)

Plant-defense molecular mechanismsFusarium circinatumPlant SciencePhytophthora xcambivoraArticleMicrobiologyplant- oomycetes- fungal interactionPlant defense against herbivoryMonterey pinePathogenEcology Evolution Behavior and Systematicshousekeeping gene<i>Phytophthora</i> <i>xcambivora</i>Housekeeping genesEcologybiologyInoculationPlant- oomycetes- fungal interactionsPinus radiataBotanySettore AGR/12 - Patologia Vegetaleplant-defense molecular mechanismbiology.organism_classificationPR3PR5Housekeeping gene<i>P. parvispora</i>QK1-989ChitinasePALbiology.proteinPitch canker diseasePhytophthoraGene expressionP. parvispora<i>Phytophthora xcambivora</i>pitch canker disease; Monterey pine; Phytophthora xcambivora; P. parvispora; plant- oomycetes- fungal interactions; gene expression; housekeeping genes; plant-defense molecular mechanisms; PR3; PR5; PAL
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The distributions of protein coding genes within chromatin domains in relation to human disease.

2019

Abstract Background Our understanding of the nuclear chromatin structure has increased hugely during the last years mainly as a consequence of the advances in chromatin conformation capture methods like Hi-C. The unprecedented resolution of genome-wide interaction maps shows functional consequences that extend the initial thought of an efficient DNA packaging mechanism: gene regulation, DNA repair, chromosomal translocations and evolutionary rearrangements seem to be only the peak of the iceberg. One key concept emerging from this research is the topologically associating domains (TADs) whose functional role in gene regulation and their association with disease is not fully untangled. Resul…

lcsh:QH426-470Computational biologyBiologyChromatin structureCell LineChromosome conformation captureOpen Reading FramesGene expressionDatabases GeneticGeneticsEnhancersHumansDiseaseEnhancerMolecular BiologyGeneRegulation of gene expressionHousekeeping genesTopologically associating domainsResearchHuman diseasesTADGenes associated with diseaseHuman geneticsChromatinChromatinHousekeeping geneGene regulationlcsh:GeneticsEnhancer Elements GeneticTranscription Initiation SiteChromatin interactionsEpigeneticschromatin
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